Substitute for Tri Chloroethylene
Tri Chloroethylene is decelerated as human carcinogen and very hard negative impacts on environment.
Hazard Summary : Acute (short-term) and chronic (long-term) inhalation exposure to trichloroethylene can affect the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. Liver, kidney, immunological, endocrine, and developmental effects have also been reported in humans. A recent analysis of available epidemiological studies reports trichloroethylene exposure to be associated with several types of cancers in humans, especially kidney, liver, cervix, and lymphatic system. Animal studies have reported increases in lung, liver, kidney, and testicular tumors and lymphoma. The Agency is currently reassessing the cancer classification of trichloroethylene. Please Note: The main source of information for this fact sheet is the Agency for Toxic Substances and Disease Registry's (ATSDR's) Toxicological Profile for Trichloroethylene. (1) Another secondary source used is EPA's Health Assessment Document for Trichloroethylene.
Cancer Risk: The cancer epidemiology for trichloroethylene has grown in recent years with several large, well-designed studies being published. A recent analysis of available epidemiological studies reports trichloroethylene exposure to be associated with several types of cancers in humans, especially kidney, liver, cervix, and lymphatic system. Consistency across epidemiological studies is strongest for an association between trichloroethylene exposure and kidney cancer. These results are supported by recent molecular epidemiology studies showing specific renal cell mutations found primarily in renal cell carcinoma patients exposed to trichloroethylene. Animal studies have reported increases in lung, liver, kidney, and testicular tumors and lymphoma from inhalation and oral exposures in rats and mice.
Reproductive/Developmental Effects
Evidence from animal and epidemiologic studies suggests that several reproductive and developmental toxicity end points may be associated with TCE exposure, including infertility in males and females, impaired fetal growth, and cardiac teratogenesis. The US Agency for Toxic Substance and Disease Registry Public Health Statement for TCE, however, does not conclude that there is a direct relationship between exposure to TCE and an increased risk of reproductive effects.
Acute Effects: Central nervous system effects are the primary effects noted from acute inhalation exposure to trichloroethylene in humans, with symptoms including sleepiness, fatigue, headache, confusion, and feelings of euphoria. Effects on the liver, kidneys, gastrointestinal system, and skin have also been noted.(1) Neurological, lung, kidney, and heart effects have been reported in animals acutely exposed to trichloroethylene. As with acute exposure, chronic exposure to trichloroethylene by inhalation also affects the human central nervous system. Case reports of intermediate and chronic occupational exposures included effects such as dizziness, headache, sleepiness, nausea, confusion, blurred vision, facial numbness, and weakness. Effects to the liver, kidneys, and immune and endocrine systems have also been seen in humans exposed to trichloroethylene occupationally or from contaminated drinking water. Studies have shown that simultaneous alcohol consumption and trichloroethylene inhalation increases the toxicity of trichloroethylene in humans. Neurological, liver, and kidney effects were reported in chronically-exposed animals. EPA is in the process of calculating a Reference Concentration (RfC) and Reference Dose (RfD) for trichloroethylene. ATSDR has calculated an intermediate-duratio 3 n inhalation minimal risk level (MRL) of 0.1 parts per million (ppm) (0.5 milligrams per cubic meter, mg/m ) for trichloroethylene based on neurological effects in rats. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non cancer health effects over a specified duration of exposure. Exposure to a level above the MRL does not mean that adverse health effects will occur. The MRL is intended to serve as a screening tool. The California Environmental Protection Agency (CalEPA) has calculated a chronic inhalation reference exposure level of 0.6 mg/m based on neurological effects in humans. The CalEPA reference exposure level is a concentration at or below which adverse health effects are not likely to occur.
Reproductive/Developmental Effects: A study of nurses occupationally exposed by inhalation to trichloroethylene along with other chemicals in operating rooms, and another epidemiological study of women exposed occupationally or no occupationally to trichloroethylene and other solvents, have reported increases in the incidence of miscarriages. The presence of other chemicals, however, limits the ability to draw conclusions specific to trichloroethylene.
Environmental Hazards
TCE most often enters the environment via fugitive emissions from metal degreasing industries and by spills or accidental releases to air, soil and water. Because of its high vapor pressure and low rate of adsorption in soil TCE evaporates fairly rapidly when released to soil. However, where it persists it can percolate rapidly through sandy soil thereby reaching groundwater.
Chemical and biological degradation of TCE in water are expected to be very slow. TCE is not expected to accumulate in aquatic organisms or to adsorb onto sediment; however it is toxic to aquatic organisms.
When released to the atmosphere, TCE remains in the vapor phase. Once in the air about half of the TCE will break down within a week. When TCE is broken down in the air, phosgene, a significant lung irritant, can be formed. In the body, TCE may break down into dichloroacetic acid, trichloroacetic acid, chloral hydrate, and 2-chloroacetaldehyde. These byproducts have been shown to be toxic to animals and may be toxic to humans.
Nimble Alternative for Tri Chloroethylene, Substitute for Tri Chloroethylene
Nimble Initiative in Developing Substitute for Tri Chloroethylene
Inspired with our mission we are committed to improve EHS standard of our customers. We had designed excellent substitute for TCE for non fuel use. Our substitute for tri chloroethylene product is totally safe for all the users irrespective of its use & application. Nimble Tri Chloroethylene alternative is a excellent fluid based on the green chemistry. Substitute for Tri Chloroethylene product designed by us is used by many industries & got excellent results. The most important feature of our alternative to Tri Chloroethylene is its non hazardous nature. TCE alterative designed by us has excellent wetting property so act as catalyst in surface cleaning. The key feature of substitute for tri chloroethylene is that it does not generate odor even it used above room temperatures. Nimble TCE substitute chemical can be used in air conditioned rooms also. By chemical properties Nimble alternative to Tri Chloroethylene is non corrosive to almost all metals & non metals. TCE substitute designed by us is neutral in PH & most importantly stable over wide temperature range.
Chemistry of the Tri Chloroethylene Substitute
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Benefits of Tri Chloroethylene substitute
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